Opportunity Information: Apply for RFA AI 19 044
The NIH Funding Opportunity Announcement RFA-AI-19-044, titled "HLA and KIR Region Genomics in Immune-Mediated Diseases (U19 Clinical Trial Not Allowed)," supports the creation and operation of a collaborative research consortium called the HLA and KIR Region Genomics in Immune Mediated Diseases Consortium (HLARGC). The main scientific goal is to deepen understanding of how genetic variation in two highly complex immune-related regions of the human genome, the HLA (also known as the Major Histocompatibility Complex, or MHC) and the KIR region, influences susceptibility to and outcomes of immune-mediated diseases. A major emphasis is placed on rigorous genomic and immunogenetic analyses that clarify disease associations and mechanisms, including clinically important outcomes after cell, tissue, and organ transplantation, where HLA and KIR variation can strongly affect immune compatibility, rejection risk, graft survival, and broader immune responses.
This opportunity uses the cooperative agreement mechanism (U19), meaning awardees are expected to work as part of a structured, multi-project team science program with substantial coordination across sites and with NIH program involvement typical of cooperative agreements. In practice, this kind of mechanism is designed for complex problems that benefit from shared standards, harmonized datasets, common analytic approaches, and coordinated dissemination of results rather than isolated, single-lab efforts. The FOA is explicitly labeled "Clinical Trial Not Allowed," which signals that the proposed work should not include prospective interventional studies assigning human participants to an intervention to evaluate health outcomes. Instead, the focus is on genomics, association studies, method development, data integration, and related non-interventional research activities that can still be highly clinically relevant (for example, analyzing existing cohorts, registries, transplant datasets, or biobanked specimens, or developing improved HLA/KIR typing and imputation strategies).
From an eligibility standpoint, the FOA is broad and inclusive of many organization types typically eligible for NIH funding. Eligible applicants include state, county, city or township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities and Indian housing authorities; nonprofit organizations both with and without 501(c)(3) status (excluding institutions of higher education in those nonprofit categories); for-profit organizations other than small businesses; and small businesses. The announcement also calls out additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions. At the same time, it draws clear lines around international participation: non-U.S. entities (foreign organizations and foreign institutions) are not eligible to apply as applicant organizations, and non-domestic components of U.S. organizations are also not eligible to apply as components. However, "foreign components" as defined by the NIH Grants Policy Statement are allowed, which typically means a U.S.-based applicant can include certain well-justified international collaborations or activities as part of the project when they materially strengthen the science and meet NIH policy requirements.
Administratively, the opportunity is categorized as discretionary funding and falls under the NIH health-related activity category, with CFDA numbers 93.853 and 93.855. The sponsoring agency is the National Institutes of Health. The FOA was created on May 2, 2019, and the original closing date listed is September 4, 2019. The posted excerpt does not specify an award ceiling or the expected number of awards, indicating those details either were not included in the provided source snippet or were defined elsewhere in the full FOA. Overall, the announcement is best understood as an NIH-driven, consortium-based effort to advance high-resolution, high-confidence understanding of HLA and KIR genomic variation in immune-mediated disease biology and transplantation outcomes, using coordinated, non-clinical-trial research approaches under a multi-project cooperative agreement structure.Apply for RFA AI 19 044
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "HLA and KIR Region Genomics in Immune-Mediated Diseases (U19 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.853, 93.855.
- This funding opportunity was created on 2019-05-02.
- Applicants must submit their applications by 2019-09-04. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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